Products for Research Use Only
RegisterLogin

DCX Antibody / Doublecortin

CAT: 0800-R32599Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R32599Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Neuronal migration protein Doublecortin, also known as Doublin or Lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Gene ID
1641
UniProt
O43602
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 74-100 (QSLRFHQNMELDFGHFDERDKTSRNMR-human) were used as the immunogen for the DCX antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the DCX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DCX antibody is available for research use only.
Storage Conditions
After reconstitution, the DCX antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the DCX antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat brain and 2) mouse brain with DCX antibody at 0.5ug/ml. Predicted molecular weight: 40-50 kDa.

UniProtKB · O43602

Neuronal migration protein doublecortin

DCX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43602
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DCX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NFY6, A9Z1V8, D3DUY8, D3DUY9, D3DUZ0, O43911, Q5JYZ5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell projectionCytoplasmMicrotubule

Molecular function

Developmental protein

Biological process

DifferentiationNeurogenesis

Disease

Disease variantEpilepsyLissencephaly

PTM

PhosphoproteinUbl conjugation

Domain

Repeat

Related Products

CatalogName
RQ4745Doublecortin Antibody / DBCN / DCX
F48191-0.4MLDCX Antibody
R35034-100UGDCX Antibody
F48191-0.08MLDCX Antibody
R34677-100UGDoublecortin Antibody
RQ4720DCLK1 Antibody / Doublecortin-like kinase 1
F44334-0.08MLDclk1 Antibody / Doublecortin-like kinase 1 / DCAMKL1
F44334-0.4MLDclk1 Antibody / Doublecortin-like kinase 1 / DCAMKL1
F55057-0.4MLDCAMKL1 Antibody / Doublecortin-like and CAM kinase-like 1 / DCLK1
F55057-0.08MLDCAMKL1 Antibody / Doublecortin-like and CAM kinase-like 1 / DCLK1

Alternative Products

CatalogName
70R-34503Doublecortin antibody

Popular Products