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CNPase Antibody / CNP

CAT: 0800-R32598Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32598Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2',3'-Cyclic-nucleotide 3'-phosphodiesterase, also known as CNPase, is an enzyme that in humans is encoded by the CNP gene. And this gene is mapped to 17q21.2. CNPase is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. CNPase is thought to play a critical role in the events leading up to myelination. Additionally, CNPase has been demonstrated to inhibit the replication of HIV-1 and other primate lentiviruses by binding the retroviral Gag protein and inhibiting the genesis of nascent viral particles.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Gene ID
1267
UniProt
P09543
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 142-178 (QYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLK-human) were used as the immunogen for the CNPase antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the CNPase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CNPase antibody is available for research use only.
Storage Conditions
After reconstitution, the CNPase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CNPase antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain, 2) mouse brain and 3) human HeLa lysate with CNPase antibody at 0.5ug/ml. Predicted molecular weight ~47 kDa.

UniProtKB · P09543

2',3'-cyclic-nucleotide 3'-phosphodiesterase

CN37_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09543
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CNP, CNPase
EC number
3.1.4.37
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationLipoproteinMethylationPhosphoproteinPrenylation

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneMitochondrion

Molecular function

HydrolaseRNA-binding

Disease

LeukodystrophyNeurodegeneration
Product Datasheet
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