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Synapsin II Antibody / SYN2

CAT: 0800-R32568Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32568Size:100 µg
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Description
Synapsin II is the collective name for synapsin IIa and synapsin IIb, two nearly identical phosphoproteins in the synapsin family that in humans are encoded by the SYN2 gene. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL
UniProt
Q92777
Host
Rabbit
Reactivity
Human, Mouse, Rat, Pig
Immunogen
Amino acids A497-D582 from the human protein were used as the immunogen for the Synapsin II antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Synapsin II antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Synapsin II antibody is available for research use only.
Storage Conditions
After reconstitution, the Synapsin II antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Differences in protocols and secondary/substrate sensitivity may require the Synapsin II antibody to be titrated for optimal performance.
Image Legend
IHC staining of FFPE pig brain tissue with Synapsin II antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q92777

Synapsin-2

SYN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92777
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A087WW96, A0A087X2E3, A8MY98
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Disease

Schizophrenia

Cellular component

Synapse

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