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PD-L1 Antibody

CAT: 0800-R32479Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32479Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Programmed death-ligand 1 (PD-L1), also known as CD274 or B7-H1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. Additionally, PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What’s more, it has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, ELISA: 0.1-0.5 µg/mL (mouse protein tested) ; request BSA-free format for coating
UniProt
Q9EP73
Host
Rabbit
Reactivity
Mouse
Immunogen
Amino acids F19-T238 from the mouse protein were used as the immunogen for the PD-L1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (protein)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Prior to reconstitution, store at 4oC. After reconstitution, the PD-L1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PD-L1 antibody is available for research use only.
Storage Conditions
Prior to reconstitution, store at 4°C. After reconstitution, the PD-L1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PD-L1 antibody should be determined by the researcher.
Image Legend
Western blot testing of mouse brain lysate with PD-L1 antibody at 0.5ug/ml. Expected molecular weight ~34/40-70 kDa (unmodified/glycosylated), observed here at 40 kDa.
Product Datasheet
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