Products for Research Use Only
RegisterLogin

Daxx Antibody

CAT: 0800-R32346Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R32346Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DAXX (death-domain associated protein) also known as DAP6 (Death-associated protein 6) or BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. Human DAXX encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses by Yang et al. (1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The DAXX gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Western blot analysis with DAXX mutants showed that the N terminus of DAXX interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunocytochemistry: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
Q9UER7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 56-345 of human Daxx were used as the immunogen for the Daxx antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Daxx antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Daxx antibody is available for research use only.
Storage Conditions
After reconstitution, the Daxx antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Daxx antibody should be determined by the researcher.
Location
Nuclear and cytoplasmic
Image Legend
Flow cytometry testing of human 293T cells with Daxx antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= Daxx antibody.

Related Products

CatalogName
V5139SAF-100UGDeath domain associated protein 6 Antibody / Daxx
V5139-100UGDeath domain associated protein 6 Antibody / Daxx
V5139-20UGDeath domain associated protein 6 Antibody / Daxx
RQ8276DAX-1 Antibody / NR0B1
R33235-100UGNR0B1 Antibody / DAX-1
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.05MLAntibody
F53954-0.2MLAntibody
F53952-0.2MLAntibody
F53952-0.05MLAntibody

Alternative Products

CatalogName
10R-1865DAXX antibody
sc-51586Daxx (DAXX-01)

Popular Products