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TSG101 Antibody

CAT: 0800-R32315Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32315Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TSG101, known as Tumor susceptibility gene 101, is mapped to 11p15. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. And the protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q99816
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids KHVRLLSRKQFQLRALMQKARKTAGLSDLY of human TSG101 were used as the immunogen for the TSG101 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the TSG101 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TSG101 antibody is available for research use only.
Storage Conditions
After reconstitution, the TSG101 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TSG101 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) human HeLa, 2) human Jurkat, 3) human K562, 4) rat brain, 5) rat PC-12, 6) mouse brain and 7) mouse NIH 3T3 cell lysate with TSG101 antibody. Predicted molecular weight ~45 kDa.

UniProtKB · Q99816

Tumor susceptibility gene 101 protein

TS101_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99816
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TSG101
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9BUM5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionGrowth regulationHost-virus interactionProtein transportTransport

Domain

Coiled coil

Cellular component

CytoplasmCytoskeletonEndosomeMembraneNucleus
Product Datasheet
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