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CRY2 Antibody / Cryptochrome 2

CAT: 0800-R32258Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32258Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. And it is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q49AN0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids RFQAIISRMELPKKPVGLVTSQQMESCRAE of human CRY2 were used as the immunogen for the CRY2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the CRY2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CRY2 antibody is available for research use only.
Storage Conditions
After reconstitution, the CRY2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CRY2 antibody should be determined by the researcher.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of 1) rat testis, 2) rat brain, 3) mouse brain, 4) human 22RV1 lysate with CRY2 antibody. Expected/observed molecular weight ~67 kDa.

UniProtKB · Q49AN0

Cryptochrome-2

CRY2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q49AN0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CRY2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DH32, B4DZD6, O75148, Q8IV71
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsSensory transductionTranscriptionTranscription regulation

Ligand

ChromophoreFADFlavoproteinNucleotide-binding

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

Photoreceptor proteinReceptorRepressor

Technical term

Proteomics identificationReference proteome

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