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SAP97 Antibody

CAT: 0800-R32206Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32206Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Disks large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene. SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane. SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function. Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q12959
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 1-165 of human SAP97 were used as the immunogen for the SAP97 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the SAP97 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SAP97 antibody is available for research use only.
Storage Conditions
After reconstitution, the SAP97 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SAP97 antibody should be determined by the researcher.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of 1) rat lung, 2) mouse lung, 3) HeLa, 4) MM231, 5) COLO320, 6) A549 and 7) mouse NIH3T3 lysate with SAP97 antibody. Predicted molecular weight: ~103 kDa, rountinely observed at ~140 kDa (Ref 1) .
Product Datasheet
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