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PSD95 Antibody / DLG4

CAT: 0800-R32167Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32167Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DLG4 (Discs large homolog 4), also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P78352
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 581-724 of human PSD95 were used as the immunogen for the PSD95 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the PSD95 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PSD95 antibody is available for research use only.
Storage Conditions
After reconstitution, the PSD95 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PSD95 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat brain, 2) mouse brain, 3) human SHG-44 and 4) human U-87 MG lysate with PSD95 antibody. Predicted molecular weight ~80 kDa but routinely observed at 90~95 kDa.

UniProtKB · P78352

Disks large homolog 4

DLG4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78352
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DLG4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z1S1, G5E939, Q92941, Q9UKK8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Disease

Disease variantIntellectual disability

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

RepeatSH3 domain

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