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CD153 Antibody / CD30L

CAT: 0800-R32072Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32072Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD153 is a ligand for CD30. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
P32971
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 63-234 of human CD153 were used as the immunogen for the CD153 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the CD153 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD153 antibody is available for research use only.
Storage Conditions
After reconstitution, the CD153 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD153 antibody should be determined by the researcher.
Location
Cytoplasmic, membrane
Image Legend
IHC testing of FFPE human tonsil with CD153 antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
Product Datasheet
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