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AT1R Antibody

CAT: 0800-R32059Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32059Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGTR1, or AT1R, is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL
UniProt
P30556
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Amino acids MILNSSTEDGIKRIQDDCPKAGRHNYIF of human AGTR1 were used as the immunogen for the AT1R antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the AT1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This AT1R antibody is available for research use only.
Storage Conditions
After reconstitution, the AT1R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the AT1R antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa and 2) mouse HEPA1-6 cell lysate with AT1R antibody. Observed molecular weight ~41-50 kDa depending on glycosylation level.

UniProtKB · P30556

Type-1 angiotensin II receptor

AGTR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30556
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AGTR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q13725, Q8TBK4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

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