Products for Research Use Only
RegisterLogin

Involucrin Antibody

CAT: 0800-R31905Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R31905Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. It is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermisand other stratified squamous epithelia. It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor during assembly of the cornified envelope. Additionally, Involucrin is synthesised in the stratum spinosum and cross linked in the stratum granulosum by the transglutaminase enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
P07476
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids QVQDIQPALPTKGEVLLPVEHQQQKQEVQWPPKHK of human Involucrin were used as the immunogen for the Involucrin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Involucrin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Involucrin antibody is available for research use only.
Storage Conditions
After reconstitution, the Involucrin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Involucrin antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) A431 and 2) A549 lysate with Involucrin antibody. Predicted molecular weight ~68 kDa but can be observed at up to ~140 kDa.

UniProtKB · P07476

Involucrin

INVO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07476
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IVL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T7P4
Protein keywords

Cellular component

Cytoplasm

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Isopeptide bondLipoprotein

Biological process

Keratinization

Domain

Repeat

Related Products

CatalogName
V5442-20UGRecombinant IVL Antibody / Involucrin
V5442SAF-100UGRecombinant IVL Antibody / Involucrin
V5442-100UGRecombinant IVL Antibody / Involucrin
RQ4624NONO Antibody / p54nrb Antibody
F53952-0.2MLAntibody
F53952-0.05MLAntibody
F53954-0.05MLAntibody
F53954-0.2MLAntibody
V8674SAF-100UGInhibin alpha Antibody / INHA antibody
V8674-100UGInhibin alpha Antibody / INHA antibody

Alternative Products

CatalogName
10R-I148aInvolucrin antibody
GWB-7C3ABDInvolucrin, Antibody

Popular Products