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Chk2 Antibody / CHEK2

CAT: 0800-R31854Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31854Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chk2 is a serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
O96017
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids KLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDL of human Chk2/CHEK2 were used as the immunogen for the Chk2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Chk2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Chk2 antibody is available for research use only.
Storage Conditions
After reconstitution, the Chk2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Chk2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of 1) rat spleen, 2) mouse testis, 3) human SW620 lysate with Chk2 antibody. Expected molecular weight: ~61 kDa.

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