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Keratocan Antibody

CAT: 0800-R31830Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31830Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Keratocan (KTN), also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene. It is mapped to 12q22. The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2) . Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
O60938
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Amino acids YLQNNLIETIPEKPFENATQLRWINLNKNKITN of human Keratocan were used as the immunogen for the Keratocan antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Keratocan antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Keratocan antibody is available for research use only.
Storage Conditions
After reconstitution, the Keratocan antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Keratocan antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) mouse testis, 2) mouse skeletal muscle, 3) human MCF7 and 4) human A549 lysate with Keratocan antibody. Predicted molecular weight ~40 kDa but the mature protein can be observed ~52 kDa with possible 34/37 kDa breakdown products. (Ref 1)

UniProtKB · O60938

Keratocan

KERA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60938
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KERA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
KTN
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Disease

Disease variant

PTM

Disulfide bondGlycoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

Domain

Leucine-rich repeatRepeatSignal

Technical term

Proteomics identificationReference proteome

Biological process

Sensory transductionVision
Product Datasheet
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