RANK Antibody

CAT: 0800-R31815Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-R31815Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Receptor Activator of NFkB (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL (Receptor Activator for NFkB Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

CAS Number

9007-83-4

Specifications

Western blot: 0.1-0.5 µg/mL, ELISA: 0.1-0.5 µg/mL (mouse protein tested) ; request BSA-free format for coating

UniProt

O35305

Host

Rabbit

Reactivity

Mouse

Immunogen

Amino acids 35-214 of mouse RANK were used as the immunogen for the RANK antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, ELISA (protein)

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the RANK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This RANK antibody is available for research use only.

Storage Conditions

After reconstitution, the RANK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the RANK antibody should be determined by the researcher.

Image Legend

Western blot testing of mouse Hepa1-6 cell lysate with RANK antibody. Predicted molecular weight ~66 kDa, routinely observed at 80~100 kDa.

UniProtKB · O35305

Tumor necrosis factor receptor superfamily member 11A

TNR11_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: O35305
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Tnfrsf11a
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q8VCT7

Protein keywords

Technical term

3D-structureReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Ligand

Metal-bindingSodium

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Product Datasheet

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