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LRRK2 Antibody

CAT: 0800-R31694Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31694Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Leucine-rich repeat kinase 2 (LRRK2), also known as Dardarin, is anenzyme that in humans is encoded by the PARK8 gene. It is a member of the leucine-rich repeat kinase family. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. It has been determined that LRRK2 possesses mixed-lineage kinase activity, and LRRK2 also showed autophosphorylation activity. Additionally, it has an affinity for lipids or lipid-associated proteins and may play a role in the biogenesis or regulation of membranous intracellular structures in the brain. It is also an IFNG target gene that may be involved in signaling pathways relevant to Crohns disease.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human partial recombinant protein (AA 10-350) was used as the immunogen for this LRRK2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the LRRK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This LRRK2 antibody is available for research use only.
Storage Conditions
After reconstitution, the LRRK2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of LRRK2 antibody and Lane 1: rat brain; 2: mouse brain; 3: (r) liver; 4: human U87; 5: (m) Neuro-2a; 6: (h) A549; 7: (h) SMMC-7721 lysate. Expected/observed size ~280KD

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