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P73 Antibody

CAT: 0800-R31648Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31648Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tumor protein 73 (TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of the protein. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate it is markedly increased by gamma-irradiation.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human partial recombinant protein (1-198) was used as the immunogen for this p73 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the p73 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This p73 antibody is available for research use only.
Storage Conditions
After reconstitution, the p73 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the p73 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of p73 antibody and Lane 1: COLO320; 2: MCF-7; 3: HeLa lysate

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