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CSK Antibody

CAT: 0800-R31527Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31527Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSK is a non-receptor protein tyrosine kinase protein that in humans is encoded by the CSK gene. It is mapped to 15q24.1. CSK suppresses activity of the Src family of protein kinases by phosphorylation of family members at a conserved C-terminal site in Src. CSKs control of the Src family activity is widely thought to be central to regulation of the immune response. It can downregulate tyrosine kinase activity of the Src oncoprotein through tyrosine phosphorylation of the carboxy terminus. Since cell transformation by Src oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the gene might function as an antioncogene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human partial recombinant protein (AA 2-204) was used as the immunogen for this CSK antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the CSK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CSK antibody is available for research use only.
Storage Conditions
After reconstitution, the CSK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CSK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CSK antibody (0.5ug/ml) and Lane 1: rat testis; 2: (r) thymus; 3: mouse liver; 4: human HeLa; 5: (h) Jurkat; 6: (h) A549; 7: (h) MCF-7; 8: (m) NIH3T3; 9: (m) Neuro-2a lysate. Predicted molecular weight: ~50kDa.

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