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IRS-1 Antibody

CAT: 0800-R31393Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31393Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Insulin receptor substrate 1 is a signalling adapter protein that in humans is encoded by the IRS1 gene. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. It also plays important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS-1 is a key regulator of PI3K within malignant cells.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P35569
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of mouse Insulin receptor substrate 1 (WYQALLQLHNRAKAHHD) was used as the immunogen for this IRS-1 antibody (100% rat homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the IRS-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IRS1 antibody is available for research use only.
Storage Conditions
After reconstitution, the IRS-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the IRS-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of IRS-1 antibody and Lane 1: HeLa; 2: A549; 3: 293T; 4: MCF-7 lysate, Expected size: 132~185KD depending on serine phosphorylation level

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