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Huntingtin Antibody / HTT

CAT: 0800-R31392Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31392Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Huntingtin gene, also called HTT or HD (Huntington disease), is the IT15 (interesting transcript 15) gene which codes for a protein called the Huntingtin. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. HTT is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. Additionally, wildtype Huntingtin may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P42858
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human HTT (ELDRRAFQSVLEVVAA) was used as the immunogen for this Huntingtin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Huntingtin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Huntingtin antibody is available for research use only.
Storage Conditions
After reconstitution, the Huntingtin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Huntingtin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Huntingtin antibody and Lane 1: human HeLa cell lysate and 2: human U-87 MG cell lysate. Predicted molecular weight: ~350 kDa.

UniProtKB · P42858

Huntingtin

HD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42858
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9UQB7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationLipoproteinMyristatePhosphoproteinUbl conjugation

Biological process

Apoptosis

Cellular component

CytoplasmCytoplasmic vesicleEndosomeNucleus

Disease

Disease variantIntellectual disabilityNeurodegeneration

Domain

Repeat

Coding sequence diversity

Triplet repeat expansion

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