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PON1 Antibody

CAT: 0800-R31377Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31377Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Paraoxonase 1, also known as Aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. This protein has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the gene significantly affect the catalytic ability of the enzyme. Paraoxonase 1 is also a major anti-atherosclerotic component of high-density lipoprotein (HDL) . The gene is activated by PPAR-gamma, which increases synthesis and release of PON1 enzyme from the liver, reducing atherosclerosis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P27169
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the middle region of human Paraoxonase 1 (FLDPYLQSWEMYLGLA) was used as the immunogen for this PON1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the PON1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PON1 antibody is available for research use only.
Storage Conditions
After reconstitution, the PON1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the PON1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of PON1 antibody and Lane 1: rat liver; 2: (r) lung; 3: human placenta; 4: (r) testis; 5: (h) HeLa; 6: mouse HEPA; 7: (h) A549; 8: (h) Jurkat; 9: (h) SKOV lysate. Expected/observed molecular weight ~40 kDa.
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