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SERPINA3 Antibody

CAT: 0800-R31341Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31341Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha 1-antichymotrypsin, also called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 or GIG24, is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. This gene is mapped to 14q32.13. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimers disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P01011
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human SERPINA3 (EMPFDPQDTHQSRFY) was used as the immunogen for this SERPINA3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the SERPINA3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SERPINA3 antibody is available for research use only.
Storage Conditions
After reconstitution, the SERPINA3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the SERPINA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of SERPINA3 antibody and SMMC-7721 cell lysate. Predicted molecular weight: 47/65kDa (unmodified/glycosylated) .

UniProtKB · P01011

Alpha-1-antichymotrypsin

AACT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01011
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SERPINA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ACT
EC number
—
Processing
Precursor
Secondary accessions
B3KVQ7, Q13703, Q2TU87, Q2TU88, Q59GP9, Q6LBY8, Q6LDT7, Q6NSC9, Q8N177, Q96DW8, Q9UC47, Q9UNU9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Acute phase

Coding sequence diversity

Alternative splicing

PTM

Glycoprotein

Molecular function

Protease inhibitorSerine protease inhibitor

Cellular component

Secreted

Domain

Signal

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