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E2F4 Antibody

CAT: 0800-R31276Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31276Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q16254
Host
Rabbit
Reactivity
Human, Rat
Immunogen
An amino acid sequence from the middle region of human E2F4 (LPKPALAQSQEASRPN) was used as the immunogen for this E2F4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the E2F4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This E2F4 antibody is available for research use only.
Storage Conditions
After reconstitution, the E2F4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the E2F4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of E2F4 antibody and Lane 1: rat lung; 2: human SMMC-7721 lysate. Expected molecular weight ~44 kDa (unmodified) and 60-65 kDa (phosphorylated) .
Product Datasheet
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