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PCSK9 Antibody

CAT: 0800-R31245Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31245Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proprotein convertase subtilisin/kexin type 9 is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. It can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
Q8NBP7
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 671-687 (AVTAVAICCRSRHLAQA-human) were used as the immunogen for this PCSK9 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the PCSK9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PCSK9 antibody is available for research use only.
Storage Conditions
After reconstitution, the PCSK9 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the PCSK9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasm, secreted
Image Legend
IHC staining of FFPE human liver cancer tissue with PCSK9 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

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