CD244 Antibody

CAT: 0800-R31168Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R31168Size:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cluster of Differentiation 244 is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al. (1999) mapped the gene to 1q22. Suzuki et al. (2008) identified a functional single-nucleotide polymorphism (SNP) in the gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al. (1999) demonstrated that engagement of CD244 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand CD244 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al. (1998) demonstrated that CD48 binds to CD244. Watzl et al. (2000) showed that antibody-mediated cross-linking of the protein leads to its rapid tyrosine phosphorylation, which is necessary for CD244-mediated killer cell activity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q9BZW8
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human Cluster of Differentiation 244 (RLSRKELENFDVYS) was used as the immunogen for this CD244 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CD244 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD244 antibody is available for research use only.
Storage Conditions
After reconstitution, the CD244 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CD244 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CD244 antbody and Lane 1: human MCF-7; 2: human HeLa lysate.
Product Datasheet
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