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DR3 Antibody

CAT: 0800-R31111Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31111Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNFRSF25 (Tumor Necrosis Factor Receptor Superfamily Member 25), also known as LARD, APO3, DR3 or TNFR25, is a protein that in humans is encoded by the TNFRSF25 gene. Members of the mammalian tumor necrosis factor receptor (TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family. By fluorescence in situ hybridization, Marsters et al. (1996) mapped the gene to 1p36.3. Marsters et al. (1996) showed that ectopic expression of DR3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B. They suggested that, like TNFR1, DR3 may regulate distinct signaling pathways in different cellular contexts.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q93038
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the N-terminus of human Death receptor 3 (CPQDTFLAWENHHNSECARCQA) was used as the immunogen for this DR3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the DR3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DR3 antibody is available for research use only.
Storage Conditions
After reconstitution, the DR3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the DR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of DR3 antbody and COLO320 lysate. Predicted molecular weight: 45 kDa, observed at 50-70 kDa.
Product Datasheet
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