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TRIF Antibody

CAT: 0800-R31108Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31108Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TICAM1 (TIR domain-containing adaptor molecule 1), also known as TRIF, is an adapter in responding to activation of toll-like receptors(TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through either NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2 . Small interfering(si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
CAS Number
9007-83-4
UniProt
Q80UF7
Host
Rabbit
Immunogen
An amino acid sequence from the C-terminus of mouse TRIF (NNHMWGHTGAQSSDDK) was used as the immunogen for this TRIF antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the TRIF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TRIF antibody is available for research use only.

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