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CRTC2 Antibody / TORC2

CAT: 0800-R31094Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31094Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CREB-Regulated Transcription Coactivator 2, also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al. (2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al. (2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1 (SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al. (2009) found that the protein functioned as a dual sensor for endoplasmic reticulum (ER) stress and fasting signals.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q53ET0
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CRTC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CRTC2 antibody is available for research use only.
Storage Conditions
After reconstitution, the CRTC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CRTC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CRTC2 antibody and human recombinant protein, 29KD with tag; Lane 1:10ng; 2: 5ng; 3: 2.5ng

UniProtKB · Q53ET0

CREB-regulated transcription coactivator 2

CRTC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53ET0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CRTC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6UUV8, Q7Z3X7, Q8N332
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

Activator

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionTranscriptionTranscription regulation

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