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OSBP Antibody

CAT: 0800-R31051Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R31051Size:100 µg
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Description
Oxysterol-Binding Protein is a protein that in humans is encoded by the OSBP gene. Im et al. (2005) reported the structure of the full-length yeast oxysterol-binding-protein Osh4, a member of the OSBP-related protein (ORP) family, at 1.5- to 1.9-angstrom resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxy cholesterol. Moreira et al. (2001) refined the localization of the OSBP1 gene to chromosome 11q12.1 by radiation hybrid analysis. Wang et al. (2005) found that OSBP functions as a cholesterol-binding scaffolding protein coordinating the activity of 2 phosphatases to control the extracellular signal-regulated kinase (ERK) signaling pathway. Cytosolic OSBP formed an approximately 440-kD oligomer with a member of the PTPPBS family of tyrosine phosphatases, the serine/threonine phosphatase PP2A, and cholesterol.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P22059
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the middle region of human Oxysterol-Binding Protein (WQKSLQYERDQRIRL) was used as the immunogen for this OSBP antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the OSBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This OSBP antibody is available for research use only.
Storage Conditions
After reconstitution, the OSBP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the OSBP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of OSBP antibody and Lane 1: rat kidney; 2: (r) spleen; 3: (r) lung; 4: human HeLa; 5: (h) A549 cell lysate

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