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GLI2 Antibody

CAT: 0800-R31041Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31041Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gli-Kruppel Family Member 2 is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel (Kr) . The Drosophila gene Kr is a member of the gap class of segmentation genes; thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al. (1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al. (2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P10070
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human GLI-2 (MLYYYGQIHMYEQDGGLENL) was used as the immunogen for this GLI2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the GLI2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GLI2 antibody is available for research use only.
Storage Conditions
After reconstitution, the GLI2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Image Legend
Western blot testing of GLI2 antibody and Lane 1: MCF-7; 2: HeLa; 3: SKOV; 4: HT1080; 5: A549 cell lysate. Predicted molecular weight: 86~168 kDa (multiple isoforms) (1) .

UniProtKB · P10070

Transcription activator GLI2

GLI2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10070
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GLI2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O60252, O60253, O60254, O60255, Q15590, Q15591, Q4JHT4
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionCiliumCytoplasmNucleus

Disease

Disease variantHoloprosencephaly

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation
Product Datasheet
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