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Prohibitin Antibody

CAT: 0800-R31032Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R31032Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prohibitin, also known as PHB1, is a protein that in humans is encoded by the PHB gene. White et al.(1991) mapped the gene to chromosome 17 by analysis of human-mouse somatic cell hybrid cell lines using a genomic fragment of human prohibitin DNA isolated from a library using the rat prohibitin cDNA clone. By in situ hybridization, they localized the gene to 17q21. Sato et al.(1992) isolated the human homolog of the rat gene and mapped it to 17q12-q21 by in situ hybridization. Proliferation of tumor cells depends on new blood vessel formation (angiogenesis) that accompanies malignant progression. Anti-cancer therapies using angiogenesis inhibitors or cytotoxic agents targeted to the vasculature of tumors have been evaluated in clinical trials. Although white fat is a nonmalignant tissue, it has the capability to quickly proliferate and expand. Furthermore, it is highly vascularized. Rupnick et al.(2002) showed that nonspecific angiogenesis inhibitors can prevent the development of obesity of mice.
CAS Number
9007-83-4
UniProt
P35232
Host
Rabbit
Immunogen
An amino acid sequence from the C-terminus of human PHB1 (KLEAAEDIAYQLSRSRN) was used as the immunogen for this Prohibitin antibody (100% homologous in human, mouse and rat).
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the Prohibitin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Prohibitin antibody is available for research use only.
Product Datasheet
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