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LASP1 Antibody

CAT: 0800-R30888Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30888Size:100 µg
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Description
LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene. This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization. LASP1 has been shown to interact with Zyxin. Northern blot analysis revealed that LASP1 mRNA was expressed at a basal level in all normal tissues examined and overexpressed in 8% of primary breast cancers. In most of these cancers, LASP1 and ERBB2 were simultaneously overexpressed.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL
UniProt
Q14847
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 16-30 (EKVNCLDKFWHKACF-human) were used as the immunogen for this LASP1 antibody (100% rat homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the LASP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This LASP1 antibody is available for research use only.
Storage Conditions
After reconstitution, the LASP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the LASP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of LASP1 antibody and Lane 1: rat liver ; 2: rat spleen; 3: rat intestine; 4: Jurkat; 5: MCF-7; 6: A431; 7: HeLa; 8: 293T. Predicted molecular weight: 30kDa.

UniProtKB · Q14847

LIM and SH3 domain protein 1

LASP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14847
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LASP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LASP-1
EC number
—
Processing
—
Secondary accessions
B4DGQ0, Q96ED2, Q96IG0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoskeleton

Biological process

Ion transportTransport

Domain

LIM domainRepeatSH3 domain

Ligand

Metal-bindingZinc

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