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FMO3 Antibody

CAT: 0800-R30857Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30857Size:100 µg
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Description
Flavin-containing Monooxygenase 3 is an enzyme that in humans is encoded by the FMO3 gene. The mammalian flavin-containing monooxygenases (FMOs) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. Flavin-containing Monooxygenase 3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine, amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P31513
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human Flavin-containing Monooxygenase 3 (DDFPNFMHNSKIQEY) was used as the immunogen for this FMO3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the FMO3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This FMO3 antibody is available for research use only.
Storage Conditions
After reconstitution, the FMO3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the FMO3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of FMO3 antibody and Lane 1: rat liver; 2: rat liver. Predicted/observed molecular weight ~60kDa.

UniProtKB · P31513

Flavin-containing monooxygenase 3

FMO3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31513
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FMO3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.13.148, 1.14.13.32, 1.14.13.8
Processing
—
Secondary accessions
B2R816, Q14854, Q8N5N5
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variant

Cellular component

Endoplasmic reticulumMembraneMicrosome

Ligand

FADFlavoproteinNADP

Molecular function

MonooxygenaseOxidoreductase

PTM

Phosphoprotein

Domain

TransmembraneTransmembrane helix

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