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SERCA1 ATPase Antibody

CAT: 0800-R30809Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30809Size:100 µg
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Description
SERCA1 (Sarcoplasmic reticulum Ca (2+) -ATPase 1, also called ATP2A1, is an enzyme that in humans is encoded by the ATP2A1 gene. This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Zhang et al. (1995) determined that the human ATP2A1 gene is 26 kb long and contains 23 exons, 1 of which can be alternatively spliced. Overexpression of S1T, but not full-length SERCA1, induced ER stress in HeLa cells and amplified ER stress through the PERK (EIF2AK3) -EIF2A -ATF4 -CHOP (DDIT3) pathway. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
O14983
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the middle region of human SERCA1 ATPase (EQREACRRACCFARVE) was used as the immunogen for this SERCA1 ATPase antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the SERCA1 ATPase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SERCA1 ATPase antibody is available for research use only.
Storage Conditions
After reconstitution, the SERCA1 ATPase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the SERCA1 ATPase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of SERCA1 ATPase antibody and Lane 1: rat skeletal muscle; 2: human PANC; 3: (h) U87 cell lysate. Observed size: 99-110KD

UniProtKB · O14983

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

AT2A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14983
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATP2A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SERCA1, SR Ca(2+)-ATPase 1
EC number
7.2.2.10
Processing
—
Secondary accessions
A8K5J9, B3KY17, O14984
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMagnesiumMetal-bindingNucleotide-binding

Biological process

Calcium transportIon transportTransport

Disease

Disease variant

PTM

Disulfide bondPhosphoprotein

Cellular component

Endoplasmic reticulumMembraneSarcoplasmic reticulum

Technical term

Proteomics identificationReference proteome

Molecular function

Translocase

Domain

TransmembraneTransmembrane helix

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