Products for Research Use Only
RegisterLogin

XRCC3 Antibody

CAT: 0800-R30783Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R30783Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
X-RAY repair, complementing defective, in chinese hamster, 3 is a DNA repair protein that in humans is encoded by the XRCC3 gene. It is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. XRCC3 function is not limited to HR initiation, but extends to later stages in formation and resolution of HR intermediates, possibly by stabilizing heteroduplex DNA. The gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q9CXE6
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of mouse XRCC3 (NQLLMRLMVDRTHEDD) was used as the immunogen for this XRCC3 antibody (100% rat homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the XRCC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This XRCC3 antibody is available for research use only.
Storage Conditions
After reconstitution, the XRCC3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the XRCC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear and cytoplasmic
Image Legend
Western blot testing of XRCC3 antibody and mouse brain lysate; Predicted molecular weight: ~38kDa.

UniProtKB · Q9CXE6

DNA repair protein XRCC3

XRCC3_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9CXE6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Xrcc3
Protein existence
2: Evidence at transcript level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

PTM

Acetylation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmMitochondrionNucleus

Biological process

DNA damageDNA recombinationDNA repair

Molecular function

DNA-binding

Technical term

Reference proteome

Related Products

CatalogName
F47295-0.08MLXRCC2 Antibody
V4944-100UGXRCC5 Antibody
RQ5784Xrcc4 Antibody
V4943-100UGXRCC5 Antibody
V4943SAF-100UGXRCC5 Antibody
RQ6077XRCC2 Antibody
V4940-100UGXRCC5 Antibody
V4942-100UGXRCC5 Antibody
F49016-0.4MLXRCC6 Antibody
V4940SAF-100UGXRCC5 Antibody

Alternative Products

CatalogName
10-2589XRCC3 antibody
GWB-EE4FACXRCC3, Antibody

Popular Products