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NUR77 Antibody

CAT: 0800-R30761Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30761Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nuclear receptor subfamily 4 group A member 1, also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, and is a member of the Nur nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the protein appears to play a key role in the survival and death of cells. Nr4a1 was overexpressed in Wnt1 -transformed mouse mammary cells. It was also induced by lithium, a Wnt1 mimic, and the promoter was activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 was not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induced genes involved in gluconeogenesis, stimulated glucose production both in vitro and in vivo, and raised blood glucose levels.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P22736
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of NUR77 alpha/NR4A1 (ASFKFEDFQVYGCY) was used as the immunogen for this NUR77 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the NUR77 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This NUR77 antibody is available for research use only.
Storage Conditions
After reconstitution, the NUR77 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the NUR77 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of NUR77 antibody and Lane 1: A431; 2: HeLa; 3: Jurkat cell lysate. Predicted molecular weight ~64/66/34kDa (isoforms 1/2/3) .
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