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Haptoglobin Antibody

CAT: 0800-R30677Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30677Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Haptoglobin is a protein that in humans is encoded by the HP gene. It is a plasma glycoprotein that binds free hemoglobin, has a tetrameric structure of 2 alpha and 2 beta polypeptides that are covalently associated by disulfide bonds. Haptoglobin is homologous to serine proteases of the chymotrypsinogen family. There are similarities between the primary structures of the alpha chain and of light chains of gamma globulins. The alpha haptoglobin locus is on the long arm of chromosome 16, where its exact cytogenetic location is 16q22.2. A major function of the protein is to bind hemoglobin (Hb) and form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P00738
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human HP (DHLKYVMLPVADQDQC) was used as the immunogen for this Haptoglobin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Haptoglobin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Haptoglobin antibody is available for research use only.
Storage Conditions
After reconstitution, the Haptoglobin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Haptoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Haptoglobin antibody and Lane 1: Raji; 2: HL-60; 3: HUT102; 4: Jurkat; 5: CEM cell lysate. Predicted molecular weight: 35-40 kDa (beta chain), 45-50 kDa (alpha + beta chain) .
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