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ATF4 Antibody

CAT: 0800-R30614Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R30614Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Activating Transcription Factor 4, also know as CREB2, belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. Members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2/ATF4 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the ATF4 protein.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P18848
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 332-351 (QYLKDLIEEVRKARGKKRVP) were used as the immunogen for this ATF4 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the ATF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ATF4 antibody is available for research use only.
Storage Conditions
After reconstitution, the ATF4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ATF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of ATF4 antibody and Lane 1: A431; 2: Raji; 3: CEM; 4: HUT cell lysate. Predicted molecular weight ~39kDa.

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