CD147 Antibody

• Description:

  Emmprin, extracellular matrix metalloproteinase inducer, also known as Emmprin (BSG) or cluster of differentiation 147 is a protein that in humans is encoded by the Emmprin gene. The gene contains 8 exons and spans 10.8 kb. This protein is a determinant for the Ok blood group system. CD147 has been shown to be an essential receptor on red blood cells for the malaria parasite. It is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, It is though also to play a role in intercellular recognition. CD147 also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. It is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.

• Specifications:

  Western blot: 0.5-1 µg/mL

• UniProt:

  P35613

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  An amino acid sequence from the middle region of human CD147 (QKTEFKVDSDDQWGEYSC) was used as the immunogen for this CD147 antibody.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  Lyophilized from 1X PBS with 2% Trehalose

• Reconstitution:

  After reconstitution, the CD147 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

• Limitations:

  This CD147 antibody is available for research use only.

• Storage Conditions:

  After reconstitution, the CD147 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

• Formulation:

  0.5 mg/mL if reconstituted with 0.2ml sterile DI water

• Applications Notes:

  The stated application concentrations are suggested starting amounts. Titration of the CD147 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot testing of CD147 antibody and human fibroma cell lysate. Predicted molecular weight: ~27 kDa (unmodified), 43-66 kDa (glycosylated) .