Collagen IV Antibody / COL4A2 (Canstatin fragment)

• Description:

  Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, is one of the six subunits of Collagen IV and possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

• UniProt:

  P08572

• Host:

  Rabbit

• Immunogen:

  An amino acid sequence from the C-terminus of human Collagen IV COL4A2 (amino acids 1697-1712: LIRTHISRCQVCMKNL) was used as the immunogen for this Collagen IV antibody (100% homologous in human, mouse and rat). This amino acid sequence is from the Canstatin fragment of the protein.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB, IHC-P

• Format:

  Antigen affinity purified

• Buffer:

  0.5mg/ml if reconstituted with 0.2ml sterile DI water

• Reconstitution:

  The lyophilized Collagen IV antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing.

• Limitations:

  This Collagen IV antibody is available for research use only.

• CAS Number:

  9007-83-4