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Bcl10 Antibody

CAT: 0800-R30577Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30577Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
O95999
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human Bcl10 (ERHFDHLRAKKILSRED) was used as the immunogen for this Bcl10 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Bcl10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Bcl10 antibody is available for research use only.
Storage Conditions
After reconstitution, the Bcl10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Bcl10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Bcl10 antibody and Lane 1: U87; 2: MCF-7; 3: HeLa; 4: COLO320 cell lysate. Observed molecular weight: 26~33 kDa.

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