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CaMKK2 Antibody

CAT: 0800-R30570Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30570Size:100 µg
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Description
Calcium/calmodulin-dependent protein kinase kinase 2, is an enzyme that in humans is encoded by the CaMKK2 gene. The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca++/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus. It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, through reduction in downstream signalling pathways and mu opioid receptor downregulation. Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss.
CAS Number
9007-83-4
UniProt
Q96RR4
Host
Rabbit
Immunogen
An amino acid sequence from the middle region of CaMKK2 (KLAYNENDNTYYAMK) was used as the immunogen for this CaMKK2 antibody (100% homologous in human, mouse and rat).
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the CaMKK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CaMKK2 antibody is available for research use only.

UniProtKB · Q96RR4

Calcium/calmodulin-dependent protein kinase kinase 2

KKCC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96RR4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAMKK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CaM-KK 2, CaM-kinase kinase 2, CaMKK 2
EC number
2.7.11.17
Processing
—
Secondary accessions
A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Molecular function

Calmodulin-bindingKinaseSerine/threonine-protein kinaseTransferase

Cellular component

Cell projectionCytoplasmNucleus

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GWB-MS954ICAMKK2 Antibody

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