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Tau Antibody / MAPT

CAT: 0800-R30554Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30554Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAPT, Microtubule-associated protein Tau, appears to be enriched in axons. The MAPT gene is assigned to chromosome 17 by hybridization of a cDNA clone to flow-sorted and spot-blotted chromosomes and to 17q21 by in situ hybridization, containing 16 exons. The Tau proteins are the product of alternative splicingfrom a single gene that in humans is designated MAPT. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons in the central nervous system and are less common elsewhere. When the proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimers disease.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P10636
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 29-44 (YTMHQDQEGDTDAGLK) were used as the immunogen for this Tau antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Tau antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Tau antibody is available for research use only.
Storage Conditions
After reconstitution, the Tau antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Tau antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Tau antibody and 1. rat brain, 2. mouse brain, 3. HT1080, 4. MCF-7 lysate. Expected molecular weight: 50-80 kDa.

UniProtKB · P10636

Microtubule-associated protein tau

TAU_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10636
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
P18518, Q14799, Q15549, Q15550, Q15551, Q1RMF6, Q53YB1, Q5CZI7, Q5XWF0, Q6QT54, Q9UDJ3, Q9UMH0, Q9UQ96
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycationGlycoproteinIsopeptide bondMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseDisease variantNeurodegenerationParkinsonism

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembraneMicrotubuleSecreted

Domain

Repeat

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