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5HT2A Receptor Antibody

CAT: 0800-R30442Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30442Size:100 µg
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Description
The mammalian HTR2A (5-HT2A receptor) is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR) . This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P28223
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human 5HT2A Receptor (AYKSSQLQMGQKKNS) was used as the immunogen for this 5HT2A Receptor antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the 5HT2A Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This 5HT2A Receptor antibody is available for research use only.
Storage Conditions
After reconstitution, the 5HT2A Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the 5HT2A Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of 5HT2A Receptor antibody and Lane 1: rat brain; 2: rat brain; 3: mouse brain; 4: mouse brain and human samples 5: U87; 6: SMMC-7721; 7: HT1080; 8: COLO320. Predicted/observed molecular weight ~53kDa.

UniProtKB · P28223

5-hydroxytryptamine receptor 2A

5HT2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28223
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTR2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
5-HT-2, 5-HT-2A
EC number
—
Processing
—
Secondary accessions
B2RAC5, B4DZ79, F5GWE8, Q5T8C0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

BehaviorHost-virus interaction

Cellular component

Cell membraneCell projectionCytoplasmic vesicleMembraneSynapse

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Domain

TransmembraneTransmembrane helix

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