14-3-3 sigma Antibody

14-3-3 sigma Antibody

• Description: 14-3-3 proteins are regulators of a diverse group of signaling proteins, including kinases, phosphatases, and transmembrane receptors, and have roles in a wide range of physiological processes including transcription, intracellular signaling, cell cycle control and apoptosis. There are seven 14-3-3 proteins in most mammals: beta, gamma epsilon, zeta, eta, sigma and tau. 14-3-3 sigma, also called Stratifin, is a product of the SFN gene. It is a tumor suppressor gene inactivated via DNA methylation. Reduced or no expression of 14-3-3 sigma is seen in various carcinoma including skin, breast and prostate, suggesting that 14-3-3 gene silencing may be involved in tumor progression.
• CAS Number: 9007-83-4
• Host: Rabbit
• Immunogen: A recombinant protein fragment from the internal region of 14-3-3 sigma was used as the immunogen for this antibody. The amino acid sequence is common to the ~30kDa and ~20kDa isoforms.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB
• Format: Purified
• Buffer: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the 14-3-3 sigma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This 14-3-3 sigma antibody is available for research use only.