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Prohibitin 2 Antibody / PHB2

CAT: 0800-F54917-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54917-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER) -selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:50-1:100, Western blot: 1:500-1:1000
UniProt
Q99623
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 225-255 from the human protein was used as the immunogen for the Prohibitin 2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Prohibitin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Prohibitin 2 antibody is available for research use only.
Storage Conditions
Aliquot the Prohibitin 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Prohibitin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
IHC testing of FFPE human colon tissue with Prohibitin 2 antibody. HIER: steam section in pH9 EDTA buffer for 20 min and allow to cool prior to staining.

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