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PHKG2 Antibody

CAT: 0800-F54915-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54915-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K) . MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100
UniProt
P15735
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 304-334 from the human protein was used as the immunogen for the PHKG2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PHKG2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PHKG2 antibody is available for research use only.
Storage Conditions
Aliquot the PHKG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the PHKG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of human HepG2 cell lysate with PHKG2 antibody. Predicted molecular weight ~44 kDa.

UniProtKB · P15735

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

PHKG2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15735
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PHKG2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PHK-gamma-LT, PHK-gamma-T
EC number
2.7.11.19
Processing
—
Secondary accessions
A8K0C7, B4DEB7, E9PEU3, P11800
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Molecular function

Calmodulin-bindingKinaseSerine/threonine-protein kinaseTransferase

Biological process

Carbohydrate metabolismGlycogen metabolism

Disease

Disease variantGlycogen storage disease

PTM

Phosphoprotein

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