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BGN Antibody / Biglycan

CAT: 0800-F54881-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54881-0.4MLSize:0.4 mL
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Description
BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:50-1:100, Western blot: 1:500-1:1000
UniProt
P21810
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 148-176 from the human protein was used as the immunogen for the BGN antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the BGN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BGN antibody is available for research use only.
Storage Conditions
Aliquot the BGN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the BGN antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human SK-BR-3 cell lysate with BGN antibody. Predicted molecular weight ~41 kDa.

UniProtKB · P21810

Biglycan

PGS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21810
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BGN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DWU3, P13247
Protein keywords

Disease

Aortic aneurysmDisease variantDwarfism

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

Domain

Leucine-rich repeatRepeatSignal

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