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REDD-1 Antibody / DDIT4

CAT: 0800-F54848-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54848-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
REDD-1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD-1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD-1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD-1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS) ; TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD-1. Thus, REDD-1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:25
UniProt
Q9NX09
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 20-49 from the human protein was used as the immunogen for the REDD-1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the REDD-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This REDD-1 antibody is available for research use only.
Storage Conditions
Aliquot the REDD-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the REDD-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human adenocarcinoma tissue with REDD-1 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

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