Presenilin 1 Antibody / PSEN1

Presenilin 1 Antibody / PSEN1

• Description: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
• CAS Number: 9007-83-4
• UniProt: P49768
• Host: Rabbit
• Immunogen: A portion of amino acids 330-359 from the human protein was used as the immunogen for the Presenilin 1 antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: IF, IHC-P, FACS, WB
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the Presenilin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This Presenilin 1 antibody is available for research use only.