Presenilin 1 Antibody / PSEN1

• Description:

  Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

• UniProt:

  P49768

• Host:

  Rabbit

• Immunogen:

  A portion of amino acids 330-359 from the human protein was used as the immunogen for the Presenilin 1 antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  IF, IHC-P, FACS, WB

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the Presenilin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Presenilin 1 antibody is available for research use only.

• CAS Number:

  9007-83-4